PHAGE THERAPY

Leveraging mathematical modeling framework to guide regimen strategy for phage therapy

Yu Z, Luong T, Banuelos S, Sue A, Ryu H, Segal R, Roach DR, Huang Q

PLOS Complex Systems 2024

Pseudomonas aeruginosa ventricular assist device infections: findings from ineffective phage therapies in five cases.

Saima Aslam, Dwayne Roach, Mikeljon P Nikolich, Biswajit Biswas, Robert T Schooley, Kimberley A Lilly-Bishop, Gregory K Rice, Regina Z Cer, Theron Hamilton, Matthew Henry, Tiffany Luong, Ann-Charlott Salabarria, Laura Sisk-Hackworth, Andrey A Filippov, Francois Lebreton, Lindsey Hall, Ran Nir-Paz, Hadil Onallah, Gilat Livni, Eran Shostak, Anat Wieder-Finesod, Dafna Yahav, Ortal Yerushalmy, Sivan Alkalay-Oren, Ron Braunstein, Leron Khalifa, Amit Rimon, Daniel Gelman, Ronen Hazan

Antimicrobial Agents and Chemotherapy 2024

Machine Learning‐Led Optimization of Combination Therapy: Confronting the Public Health Threat of Extensively Drug Resistant Gram‐Negative Bacteria.

Nicholas M Smith, Thomas D Nguyen, Thomas P Lodise, Liang Chen, Jan Naseer Kaur, John F Klem, Katie Rose Boissonneault, Patricia N Holden, Dwayne R Roach, Brian T Tsuji

Clinical Pharmacology & Therapeutics 2024

Rapid Bench to Bedside Therapeutic Bacteriophage Production.

Tiffany Luong, Andrew D Sue, Dwayne R Roach

Bacteriophage Therapy: From Lab to Clinical Practice 2023

A Mechanism-based Pathway Toward Administering Highly Active N-Phage Cocktails.

Nicholas M Smith, Thomas D Nguyen, Wai Hoe Chin, Jacob T Sanborn, Harriet de Souza, Brian M Ho, Tiffany Luong, Dwayne R Roach

Frontiers in Microbiology 2023

Phage therapy in the resistance era: where do we stand and where are we going?

Tiffany Luong, Ann-Charlott Salabarria, Dwayne Roach
Clinical Therapeutics 2020

Standardized bacteriophage purification for personalized phage therapy.

Tiffany Luong, Ann-Charlott Salabarria, Robert Edwards, Dwayne Roach
Nature Protocols 2020

Stronger Together? Perspectives on phage-antibiotic synergy in clinical applications of phage therapy.

Anca Segall, Dwayne Roach, Stephanie Strathdee
Current Opinion in Microbiology 2019

Design of a broad-range bacteriophage cocktail that reduces Pseudomonas aeruginosa acute biofilms and treats infections in two animal models.

Francesca Forti, Dwayne Roach, Marco Cafora, Maria Pasini, David horner, Ersilia Fiscarelli, Martina Rossitto, Lisa Cariani, Federica Briani, Laurent Debarbieux, Daniela Ghisotti
Antimicrobial Agents & Chemotherapy 2018

Synergy between the host immune system and bacteriophage is essential for successful phage therapy against an acute respiratory pathogen.

Dwayne Roach, Chung Yin Leung, Marine Henry, Eric Morello, Devika Singh, James Di Santo, Joshua Weitz, Laurent Debarbieux

Cell Host & Microbe 2017

THIS WEEK IN MICROBIOLOGY TWiM #159: Immunophage synergy

00:00 / 1:00:36

BacterioFiles 336: Phages Fortify Friendly Fighters

00:00 / 14:07

Phage therapy: awakening a sleeping giant.

Dwayne Roach, Laurent Debarbieux

Emerging Topics in Life Sciences 2017

Triple-acting lytic enzyme treatment of drug-resistant and intracellular Staphylococcus aureus.

Stephen Becker, Dwayne Roach, Vinita Chauhan, Yang Shen, Juli Foster-Frey, Anne Powell, Gary Bauchan, Richard Lease, Homan Mohammadi, William Harty, Chad Simmons, Mathias Schmelcher, Mary Camp, Shengli Dong, John Baker, Tamsin Sheen, Kelly Doran, David Pritchard, Raul Almeida, Daniel Nelson, Ian Marriott, Jean Lee, David Donovan

Scientific Reports 2016

Antimicrobial bacteriophage-derived proteins and therapeutic applications.

Dwayne Roach, David Donovan

Bacteriophage 2015